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With regard to the relationship between BDNF and depressive disorders, there is evidence that expression and activity of BDNF in the hippocampus are decreased in response to stress and increased by antidepressant treatment [40,41,42,43]

This review provides current insights into kefirs and their recent updates on their health-promoting effects, comparing milk and water kefir for their processing, microbiological composition and current application of exopolysaccharides of milk kefir in the food industry